Descending pain inhibitory pathways



  • Stimulation produced analgesia (SPA)
    Ventrobasla thalamus, Internal capsule
    PAG (Periaqueductal gray matter) -> rostroventral medulla
    NRM (serotonergic Nucleus raphe magnus, input from PAG)
    Nucleus paragigantocellularis
    descending through dorsolateral funiculus
    -> inhibiting neurons in SC layers 1, 2, 3
  • Opiate analgesia
    Morphine투여 at above system
    Opiate receptor가 있다.
  • endogenous opioid pedptides : three classes
    all contain the sequence Tyr-Gly-Gly-Phe
    Endorphins,
    Enkephalins,
    Dynorphin family


priviously